Moreover, total acidity of extract treated group 60. Pretreatment of the ethanol induced ulcer with girinimbine reduced the no concentration in the plasma and elevated pge 2 together with a decreased level of tnf. Protective effect of sucralfate against alcoholinduced gastric mucosal injury in the rat. Asuzu2 1department of veterinary pharmacology and toxicology, university of abuja, pmb 117 abuja, nigeria. Antiulcerogenic activities of agelanthus dodoneifolius leaf. The effect of oral administration of raw camel milk 5 mlkg b. Pdf protective effects of ginkgo biloba extract on the.
Ethanol etoh and aspirin asp ulcer induction the ethanol induced ulcer was carried in rats by administering ethanol as described by hollander et al. Amelioration of ethanolinduced gastric ulcers in rats pretreated. Pdf gastroprotective effects of pistacia atlantica extract on. Effect of garlic oil on ethanol induced gastric ulcers in rats. It is concluded that myristica fragrans showed significant protecting activity in ethanol induced ulcer. Rats were classified into non ovariectomized and ovariectomized negative control groups, positive control groups where ulcer was induced by 10 ml kgg1 ethanol 50% p. Daniel and his colleagues induced ulcer with ethanol in rats to. The chemical profile of the extract was determined by hplcpadesiitms. Exposure of rats to ethanol resulted in gastric mucosal injury and a high index of ulcer. The gastroprotective potential of minocycline was assessed against ethanol 1 ml of 100% ethanol induced gastric mucosal damage by following the method of natale et al 31. The ameliorative effect of dates phoenix dactylifera l. Ulcer index of extract treated rats was improved 41. As shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat. Thirty wistar rats were divided into six groups of five rats each.
Kaempferol protects ethanolinduced gastric ulcers in mice via pro. In alcohol induced ulcer model, ranitidine 30mg mgkg significantly reduced the ulcer index whereas aero7d inhibit the ulcer index significantly at the doses 800, 400mg kg p rats. Oral pretreatment with zingerone attenuated the number and the length of gastric lesions in a dosedepended manner p arthrospira spirulina maxima have attracted attention because of their potential therapeutic antioxidant properties. Gastric ulceration was induced using 80% ethanol after a pilot study was done to identify which ulcer inducing agents would induce the most ulceration with minimal mortality in one hour. According to yonei and guth 1 the gastric submucosal microvascular disturbance resulting in local ische. Original article aripiprazole an atypical antipsychotic. Ethanol induced hyperemia was markedly reduced by lipoxygenaseselective inhibitors bw755c or nordihydroguaiaretic acid, or by the h 1antihistamine pyrilamine, but not by indomethacin, cimetidine, phentolamine, or methysergide. Archana devi department of pharmaceutical chemistry, teegala krishna reddy college of pharmacy, medbowli, meerpet, saroornagar, ranga reddy, a. The pretreatment of rats with low and high doses of c. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Animals were randomly divided into four groups each of 6 rats. The antiulcer activity was assessed by determining and comparing the ulcer index in the test. Group ii animals served as ulcerogenic group received ethanol orally. The animals were sacrificed after 4 hr and functional indices of ulcer activity was studied in all rats and compared with that of nonulcer induced ones.
The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. A doseeffect relation was constructed using the ethanolinduced gastric ulcer model in male wistar rats. The present work was done to investigate the possible effects of nigella sativa oil nso on gastric secretion and ethanolinduced ulcer in rats. The gastro protective effects of cibotium barometz hair on. The rats were fasted for 24 hours before the oral gavage pretreatment food but not water. Pretreatment with ari significantly p gastric lesions induced by ethanol and also resulted in a significant decrease in the gastric secretion, and total acidity in pylorus ligated rats. Prevention of hclethanol induced gastric mucosal injury in. Water supplement had been removed two hours before oral pretreatment started. Pdf protective role of phoenix dactylifera fruit against. Ethanolinduced rodent gastric ulcer model creative biolabs.
Cibotium barometz is a medical herb used traditionally in the malaysian peninsula for several ailments, including gastric ulcer. The effect of oq extract on gastric ulcer in rats in pylorus ligation induced and ethanol induced models was studied using single dosing 100, 200, 400. Rats were sacrificed 1 hour later with excess of ether. Inbred matured albino wister rat of both sexes weighing 150. For testing or evaluating antipeptic ulcer activity of potential drug candidates, many rodent models have been applied including nasaidsinduced gastric ulcer models, ethanolinduced gastric ulcer models and so on.
Evaluation of gastroprotective activity of myristica fragrans on. Gastroprotective effect of zingerone on ethanolinduced. The mucus content of gastric mucosa in rats treated with ethanol ulcer control group was significantly reduced when compared to positive control or the extract groups. Four groups of male sprague dawley rats each consist of 6 animals. Ethanol is considered a risk factor for developing gastric ulcers. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of nonsteroidal antiinflammatory drugs. Diosmin attenuates gastric histopathologic aberrations and influx of leukocytes the current study next explored whether dio can protect against the histopathologic damage associated with ethanolinduced gastric injury in rats. The ethanolic extract of commiphora caudata bark extract was evaluated for their cytoprotective activity against ethanolinduced gastric lesions in rats. Antiulcerogenic effect of camel milk against ethanol induced. In addition, the composition of cesb was clarified by highperformance liquid chromatography hplc. After the treatment period, rats received oral administration of 1. Group i served as control group received saline orally.
Anti ulcer activity of centella asiatica leaf extract against ethanol induced gastric mucosal injury in rats. Diazoxide, a katp channel opener, prevented ethanolinduced. Evaluation of gastroprotective activity of myristica. Evaluation of antiulcer activity of moringa oleifera seed extract. Based on these results, a model for the pathogenesis of ethanol induced gastric lesions is proposed. Ethanol extract from the leaf 20 0 mgkg bodyweight of gongronema latifolium was administered to both streptozotocin induced diabetic and control groups orally for 14 days. Gastric acid secretion was measured and ulcer was induced using ethanol and fourhour pyloric ligation.
Gastric ulcer was induced in overnight fasted rats that. Mar 30, 2015 diosmin lowers ulcer index a and area of gastric lesions b in rats with ethanolinduced gastric injury. Protective role of phoenix dactylifera fruit against ethanolinduced. Peptic ulcers are gastrointestinal lesions that occur in the. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanolinduced gastric ulcers in rats. Protective effects of ginkgo biloba extract on the ethanolinduced gastric ulcer in rats. Anti ulcer activity of swietenia mahagoni leaf extract in ethanol induced gastric mucosal damage in rats. Studies on the mechanism of ethanolinduced gastric damage in. Gastroprotective activity of aqueous carica papaya seed. Research paper ulcer prevention effect of 3,4,5tihydroxyn0. Research article ethanolinduced gastric ulcer in male wistar. Gastric lesions were induced with ethanol 96% at a dose of 0. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat. Antiulcer activity of pisonia aculeata on pylorus ligation induced gastric ulcer in rats ch.
Pdf gastroprotective effect of zingerone on ethanol. Ethanolinduced gastric ulceration in rats semantic scholar. Pdf antiulcerogenic effect of cuphea ignea extract. Therapeutic effect of momordica balsamina leaf extract on ethanolinduced gastric ulcer in wistar rats background. Effect of garlic oil on ethanol induced gastric ulcers in rats article in phytotherapy research 181. The collected samples of raw milk were kept at room temperature 25c and examined for physiochemical parameters as well as sensory evaluation. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced by ethanol in rats. Antiulcerogenic effect of camel milk against ethanol induced gastric ulcers in rats. Diosmin protects against ethanolinduced gastric injury in. Antiulcerogenic activity of scutia buxifolia on gastric. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. This was associated with a reduction of mda, which was elevated by the administration of ethanol.
Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found. Treatment and induction of gastric ulcer with hclethanol the experiment was designed having 6 groups while 6 rats were randomly allotted to each group. Seeds extract of moringa oleifera was administered in the dose of 150 and 200 mgkg orally. Study of the protective effects of flaxseed oil on ethanol.
Alkofahi 1999 showed that all of the effective sem and tested. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and. The stomachs were isolated, washed gently under clean. Antiulcer activity of pisonia aculeata on pylorus ligation. At creative biolabs, we offer ethanolinduced gastric ulcer models induced in both rats and mice. This study was performed to investigate the regular treatment of oral administration of raw camel milk 5 mgkg b. The effect of nicotine on ethanolinduced gastric ulcers in rats. Therapeutic value of camel milk as antiulcerogenic effect. Antioxidant properties and gastroprotective effects of 2. Evaluation of the antiulcer effect of aerva javanica aerial. Girinimbine from curry leaves promotes gastro protection. Pdf gastroprotective effects of betanin against ethanol. Antiulcer activity of seeds of moringa oleifera was studied in rats in which gastric ulcers were induced by oral administration of ethanol and pylorus ligation. Nazarbahjat n, kadir fa, ariffin a, abdulla ma, abdullah z, yehye wa 2016 antioxidant properties and gastroprotective effects of 2 ethylthiobenzohydrazones on ethanolinduced acute gastric mucosal lesions in rats.
Ethanol induced gastric lesions cytoprotection studies. Same design was used for ethanol model using ethanol. Protective effect of falcaria vulgaris extract on ethanol. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, adoekiti were used. Therapeutic effect of momordica balsamina leaf extract on. The percentage ulcer inhibition was significantly high p rats treated with the extract when compared with the control and the effect is similar to that of rats treated with cimetidine. Ethanol induced ulcer the effects of aero7d at various doses were studied in ethanol induced ulcer in rats were shown on table 2. It readily penetrates the gastric mucosa due to its ability to solubilize the protective mucous and expose the mucosa to the proteolytic and hydrolytic actions of hydrochloric acid and pepsin, causing damage to the membrane. Original article gastroprotective effect of minocycline in. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. Pdf antiulcerogenic activity of scutia buxifolia on gastric. Gastroprotective effect of zingerone on ethanolinduced gastric.
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